In many patients, the predominance of cytokines is associated with tissue destruction, including interleukin 6 and tumor necrosis factor, which implies the possibility of a better response to biological agents that act on these factors.
The prevalence of JRA has been estimated in 10-20 cases per 100,000 children; Pauciarticular and polyarticular disease occur more frequently in girls Flekosteel, whereas systemic onset disease affects both sexes equally.
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